| Antibody | Spike Protein Target Region | Mechanism of Action | References |
| S2H97 | Stem Helix | Blocks membrane fusion | |
| S2P6 | Stem Helix | Blocks membrane fusion | |
| CC25.106, CC95.108, CC99.103, CC68.109, CC40.8, CV3-25 | Stem Helix | Blocks membrane fusion | |
| DH1047 | Fusion Peptide | Prevents viral entry | |
| COV44-62 | Fusion Peptide | Prevents viral entry | |
| B12 | Fusion Peptide | Prevents viral entry | Diaz 2025 |
| 76E1 | Fusion Peptide | Prevents viral entry | Sun 2025 |
| CoVIC-154 | Fusion Loop | Prevents viral entry | Schendel 2025 |
| 54043-5 | HR1/Central helix junction | Blocks conformational changes | Johnson 2024 |
| RAY53 | Hinge Region | Blocks viral entry through an Fc-mediated response | Silva 2023 |
| Nanobody 79C11 | HR1 region | Prevents spike-mediated cell fusion; likely disrupts HR1-HR2 interaction | Feng 2025 |
| B6 | Downstream of Furin Cleavage Site | Spike protein cleavage | Diaz 2025 |
| B13 | Stem Helix adjacent to HR2 | Prevents viral fusion and entry | Diaz 2025 |
| CoVIC-364, CoVIC-161, CoVIC-210 | Full trimeric spike protein | Prevents viral fusion and entry | Schendel 2025 |