Leno-Duran 2024 identified increased expression of biomarkers associated with T-lymphocyte function (ADA, CD8α, IL-17C and CCL25) following BNT162b2 vaccination in healthcare workers; higher baseline levels of MCP-2 were associated with a higher mean antibody titer following vaccination in this same cohort, while higher baseline levels of HGF and CD6 were associated with lower mean antibody titers following vaccination.
Milestone
2.6.g
Multiple biomarkers
In progress
Determine whether multiple biomarkers are needed to enhance the performance of a CoP in predicting the efficacy of SARS-CoV-2 or broadly protective coronavirus vaccines, including neutralizing antibodies, memory B cells, Fc effector antibodies, and CD4 and CD8 T cells.
Progress Highlights
Li 2024 identified increased antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent neutrophil phagocytosis (ADNP) activity in CoronaVac recipients without breakthrough infections; when incorporated into a prognostic model, ADNP demonstrated effective predictive ability in distinguishing COVID-19 patients with fatal and non-fatal outcomes.