Mao 2023 compared eighteen COVID-19 vaccine candidate launch timelines emphasized the importance of including LMICs in the decision-making process of global procurement and delivery, strengthening the WHO prequalification and Emergency Use Listing programs, and ensuring LMICs have robust and transparent regulatory systems in order accelerate launch timelines.
Milestone
3.2.a
Candidate prioritization
In progress
Define principles that can be used by funders and developers to down-select vaccine candidates for further evaluation. These principles should consider issues such as complexity of manufacturing, key challenges with vaccine distribution and use, and the end goals for using different vaccines. All of these issues influence the ability of vaccines to be manufactured and used in different global regions, including in LMICs.
Progress Highlights
CEPI has established “BPCV Stage Gate Criteria” for pan-sarbecovirus vaccines, which contain benchmarks for preclinical testing, including immunological endpoints, as well as guidelines for meeting regulatory and legal requirements for clinical trials